MovDisordV3, Main, Exploration, bibRecord, 003A00

Brain atrophy rates in Parkinson's disease with and without dementia using serial magnetic resonance imaging

Identifieur interne : 003A00 ( Main/Exploration ); précédent : 003999; suivant : 003A01

Brain atrophy rates in Parkinson's disease with and without dementia using serial magnetic resonance imaging

Auteurs : Emma J. Burton [Royaume-Uni] ; Ian G. Mckeith [Royaume-Uni] ; David J. Burn [Royaume-Uni] ; John T. O'Brien [Royaume-Uni]

Source :

Movement Disorders [ 0885-3185 ] ; 2005-12.

RBID : ISTEX:2C6F45263D238D81F41B33225A241B7DC55D9D17

Descripteurs français

Pascal (Inist)
- Atrophie, Démence, Imagerie RMN, Parkinson maladie, Système nerveux pathologie.

English descriptors

KwdEn :
- Aged, Atrophy, Atrophy (pathology), Brain (pathology), Case-Control Studies, Dementia, Dementia (complications), Dementia (pathology), Demography, Disease Progression, Female, Follow-Up Studies, Humans, Magnetic Resonance Imaging, Male, Mental Status Schedule, Nervous system diseases, Neurologic Examination, Neuropsychological Tests, Nuclear magnetic resonance imaging, Parkinson Disease (complications), Parkinson Disease (pathology), Parkinson disease, Parkinson's disease dementia, serial MRI.
MESH :
- complications : Dementia, Parkinson Disease.
- pathology : Atrophy, Brain, Dementia, Parkinson Disease.
- Aged, Case-Control Studies, Demography, Disease Progression, Female, Follow-Up Studies, Humans, Magnetic Resonance Imaging, Male, Mental Status Schedule, Neurologic Examination, Neuropsychological Tests.

Abstract

Increased rates of brain atrophy are seen in Alzheimer's disease, but whether rates are similarly increased in other dementias such as Parkinson's disease dementia (PDD) has not been well examined. We determined the rates of brain atrophy using serial magnetic resonance imaging (MRI) in PDD and compared this finding to rates seen in cognitively intact Parkinson's disease (PD) patients and age‐matched control subjects. Thirty‐one patients (PD = 18, PDD = 13) and 24 age‐matched controls underwent serial volumetric 1.5 T MRI scans, approximately 1 year apart. Baseline and repeat scans were registered and quantification of the brain boundary shift integral was used to determine whole‐brain atrophy rates. Rates of brain atrophy were significantly increased in PDD (1.12 ± 0.98%/year) compared to PD (0.31 ± 0.69%/year; P = 0.018) and control subjects (0.34 ± 0.76%/year; P = 0.015). There were no differences in atrophy rates between controls and PD (P = 0.79). No correlations between increased atrophy rates and age or dementia severity (Mini‐Mental State Examination score) were observed. Serial MRI may be a useful tool for monitoring disease progression in PDD and further studies should investigate its utility for early diagnosis. © 2005 Movement Disorder Society

Url:

https://api.istex.fr/document/2C6F45263D238D81F41B33225A241B7DC55D9D17/fulltext/pdf

DOI: 10.1002/mds.20652

Affiliations:

Royaume-Uni

Le document en format XML

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<front><div type="abstract" xml:lang="en">Increased rates of brain atrophy are seen in Alzheimer's disease, but whether rates are similarly increased in other dementias such as Parkinson's disease dementia (PDD) has not been well examined. We determined the rates of brain atrophy using serial magnetic resonance imaging (MRI) in PDD and compared this finding to rates seen in cognitively intact Parkinson's disease (PD) patients and age‐matched control subjects. Thirty‐one patients (PD = 18, PDD = 13) and 24 age‐matched controls underwent serial volumetric 1.5 T MRI scans, approximately 1 year apart. Baseline and repeat scans were registered and quantification of the brain boundary shift integral was used to determine whole‐brain atrophy rates. Rates of brain atrophy were significantly increased in PDD (1.12 ± 0.98%/year) compared to PD (0.31 ± 0.69%/year; P = 0.018) and control subjects (0.34 ± 0.76%/year; P = 0.015). There were no differences in atrophy rates between controls and PD (P = 0.79). No correlations between increased atrophy rates and age or dementia severity (Mini‐Mental State Examination score) were observed. Serial MRI may be a useful tool for monitoring disease progression in PDD and further studies should investigate its utility for early diagnosis. © 2005 Movement Disorder Society</div>
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Movement Disorders (revue)

Brain atrophy rates in Parkinson's disease with and without dementia using serial magnetic resonance imaging

Brain atrophy rates in Parkinson's disease with and without dementia using serial magnetic resonance imaging

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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